Antibodies to thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) occur in many different thyroid diseases and in some healthy individuals. The measurement of both TgAb and TPOAb can be of value in the diagnosis of autoimmune thyroiditis (Hashimotos Disease), Graves Disease, endemic goiter, and subacute thyroiditis. These measurements, when used as part of a thyroid autoimmune diagnostic profile (including TRAb) can be useful in the differential diagnosis and management of thyroid disease. Assessment of Tg and TPO antibodies may also be of value in the following disease diagnoses: Addisons Disease, Type 1 diabetes mellitus, polyendocrine autoimmunopathies, members of families prone to organ specific autoimmunity, and thyroid autoimmunity in pregnancy.
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Last Updated : 03/16/2013