FOLLISTATIN 288 Antibody MCA4736GA
Company : AbD Serotec Inc
UMDC Code : 451741
MCA4736GA recognises human follistatin isoform 288 (FS288). Follistatin (FST) is a single-chain glycosylated protein of gonadal origin, originally identified as an antagonist of activin and suppressor of follicle stimulating hormone (FSH) synthesis/secretion. Alternative splicing of FST mRNA generates the two isoforms FS315 and FS288, the latter of which is the main cell-surface form and binds with high affinity to surface heparan sulphate proteoglycans, whilst FS315 binds with only low-affinity, and is considered to be the main circulating form of follistatin.
As well as activin, FST interacts with other growth factors such as bone morphogenetic proteins (BMPs) -2, -4 and -7, myostatin, and growth differentiation factor 9 (GDF-9), playing a key role in cellular differentiation/proliferation, embryonic development and tissue repair. Clone 17/2 has been shown to exhibit 10% cross-reactivity with FS315 in an immunoassay.
Product URL : http://www.abdserotec.com/product/17-2-anti-follis
Last Updated : 03/16/2013