MCA216F reacts with the CGM6 gene product of the carcinoembryonic gene family. This is a 100kD, GPI anchored molecule expressed on peripheral blood polymorphonuclear cells. The antigen is expressed strongly by mature granulocytes and meta-myelocytes, but only weakly by bone marrow myelocytes. Peripheral blood monocytes and lymphocytes do not express significant amounts of the antigen. The antibody reacts with cells from CML in the chronic phase. The CD67 cluster was re-designated as CD66b at the Vth Leucocyte Typing Workshop in Boston, 1993.
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Last Updated : 03/16/2013