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Anti Thyroid Peroxidase (TPO) ELISA

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Product Literature/Brochure from GenWay Biotech Inc

Thyroid peroxidase (TPO) present at the apical plasma membrane of human thyroid cells catalyzes the first step in thyroid hormone synthesis. TPO oxidizes iodide-anions and iodinates some tyrosyl residues of thyreoglobulin (TG), leading to the formation of monoiodotyrosine (MIT) and diiodotyrosine (DIT). Coupling of MIT and DIT yields triiodotyronine (T3) and tetra-iodotyronine (T4). TPO (previously known as thyroid microsomal antigen) is a frequent epitope of autoantibodies in autoimmune thyroid disease. The quantitative immunoenzymatic determination of autoantibodies to TPO is based on the ELISA (Enzyme-linked Immunosorbent Assay) technique. Microtiter strips are precoated with recombinant thyroid peroxidase (TPO) to bind corresponding antibodies of the specimen.

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