Home > Specialties > IVD Test Reagent/Kits, Cytology/Histology, Seminal Fluid, DNA Fragmentation

IVD Test Reagent/Kits, Cytology/Histology, Seminal Fluid, DNA Fragmentation

Definition : Reagents used in cytology and/or histology assays to determine sperm (i.e., spermatozoa) chromosome DNA strand fragmentation (i.e., lack of integrity) and/or other DNA damage present in the seminal fluid. Reagents used in sperm chromatin dispersion (SCD) tests typically consist of a kit including devices such as Eppendorf tubes, slides, and reagents consisting of denaturing and lysing solutions, stains, and ethanol. The DNA disruption is assessed on dried slides using a light microscope. Other methods of testing sperm DNA fragmentation are also available, such as those based on (1) sperm chromatin structure assay (SCSA); (2) terminal deoxynucleotidyl transferase TdT-mediated deoxyuridine triphosphate (dUTP) nick end labeling (known as TUNEL assay); and (3) a single-cell gel electrophoresis assay (known as the COMET assay). All these methods use flow-cytometry and/or microscopes for assessing the results.

Entry Terms : "DNA Disruption Seminal Flow Determination Cytology/Histology Reagents" , "DNA Fragmentation Seminal Flow Determination Cytology/Histology Reagents" , "IVD Test Reagent/Kits, Cytology/Histology, Seminal Fluid DNA Disruption" , "Seminal Fluid Assessment Reagents" , "Spermatozoid DNA Disruption Determination Reagents" , "Spermatozoid DNA Fragmentation Determination Reagents"

UMDC code : 28043

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BD

Company Type: Parent

BD is a medical technology company that serves healthcare institutions, life science researchers, clinical laboratories, industry and the general public.

Mayo Medical Laboratories

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