Reagents, Hematology, Coagulation, Thrombophilia Marker, Activated Protein C Resistance
Definition : Hematology reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (typically plasma) to determine the resistance to activated protein C (APC), usually defined as a low normalized sensitivity APC ratio (e.g., lower than 0.84 in functional testing). The most frequent cause by far of activated protein C resistance (APCR) is the presence of a mutated coagulation factor V (known as factor V Leiden) that is resistant to degradation by activated protein C. APCR is a major risk factor for venous thrombosis and the most common known genetic cause of thrombophilia; APCR may also occur in some diseases (e.g., cancer, diabetes, AIDS) and temporarily during pregnancy.
Entry Terms : "Protein C (Activated) Resistance (APC Resistance) Determination Reagents" , "APC Resistance (Activated Protein C Resistance) Determination Reagents" , "Activated Protein C Resistance Determination Reagents"
UMDC code : 19749