Molecular Microarrays, Comparative Genomic
Definition : Microarrays designed to detect genomic gains or losses or changes in the number of copies of a particular gene associated with a disease. The packet samples on the microarray spots consist of large immobilized pieces of DNA with a known chromosomal location for each spot. DNA-labeled samples from normal and diseased tissues are hybridized to the array; an expression pattern with more bright spots indicates that the number of genes involved in the disease has increased. Expression pattern comparative genomic molecular microarrays can be used to determine the extent and/or follow the progress of particular diseases (e.g., cancer tumors).
Entry Terms : "Comparative Genomic Hybridization (CGH) Microarrays"
UMDC code : 20818