IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG, AR Gene
Definition : Molecular assay reagents intended to identify CAG repeats in the androgen receptor (AR) gene, located at chromosome Xq11-q12. A variation from the expected number of normal CAG trinucleotide repeat copies may produce altered DNA and improper gene functioniing, resulting in full mutation. Normal alleles have from10 to 36 CAG repeats. Alleles with from 38 to more than 60 CAG trinucleotide repeats have been associated with spinobulbar muscular atrophy (Kennedy's syndrome)
Entry Terms : "Kennedy Disease Gene Mutation Reagents" , "Muscular Atrophy Gene Mutation Reagents" , "Spinobulbar Muscular Atrophy (SBMA) Gene Mutation Reagents" , "Reagents, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG, AR Gene"
UMDC code : 25022